126 results
VaTEST III: Validation of 8 Potential Super-Earths from TESS Data
- Priyashkumar Mistry, Aniket Prasad, Mousam Maity, Kamlesh Pathak, Sarvesh Gharat, Georgios Lekkas, Surendra Bhattarai, Dhruv Kumar, Jack J. Lissauer, Joseph D. Twicken, Abderahmane Soubkiou, Francisco J. Pozuelos, Jon Jenkins, Keith Horne, Steven Giacalone, Khalid Barkaoui, Mathilde Timmermans, Cristilyn N. Watkins, Ramotholo Sefako, Karen A. Collins, David R. Ciardi, Catherine A. Clark, Boris S. Safonov, Avi Shporer, Joshua E. Schlieder, Zouhair Benkhaldoun, Chris Stockdale, Carl Ziegler, Emily A. Gilbert, Emmanuël Jehin, Felipe Murgas, Ian J. M. Crossfield, Martin Paegert, Michael B. Lund, Norio Narita, Richard P. Schwarz, Robert F. Goeke, Sergio B. Fajardo-Acosta, Steve B. Howell, Thiam-Guan Tan, Thomas Barclay, Yugo Kawai
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- Journal:
- Publications of the Astronomical Society of Australia / Accepted manuscript
- Published online by Cambridge University Press:
- 11 April 2024, pp. 1-22
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NASA’s all-sky survey mission, the Transiting Exoplanet Survey Satellite (TESS), is specifically engineered to detect exoplanets that transit bright stars. Thus far, TESS has successfully identified approximately 400 transiting exoplanets, in addition to roughly 6000 candidate exoplanets pending confirmation. In this study, we present the results of our ongoing project, the Validation of Transiting Exoplanets using Statistical Tools (VaTEST). Our dedicated effort is focused on the confirmation and characterization of new exoplanets through the application of statistical validation tools. Through a combination of ground-based telescope data, high-resolution imaging, and the utilization of the statistical validation tool known as TRICERATOPS, we have successfully discovered eight potential super-Earths. These planets bear the designations: TOI-238b ( R⊕), TOI-771b ( R⊕), TOI-871b ( R⊕), TOI-1467b ( R⊕), TOI-1739b ( R⊕), TOI-2068b ( R⊕), TOI-4559b ( R⊕), and TOI-5799b ( R⊕). Among all these planets, six of them fall within the region known as ’keystone planets,’ which makes them particularly interesting for study. Based on the location of TOI-771b and TOI-4559b below the radius valley we characterized them as likely super-Earths, though radial velocity mass measurements for these planets will provide more details about their characterization. It is noteworthy that planets within the size range investigated herein are absent from our own solar system, making their study crucial for gaining insights into the evolutionary stages between Earth and Neptune.
Chapter 4 - Contribution of RADx® Tech to the Rapid Development of COVID-19 Diagnostic Tests
- Edited by Steven C. Schachter, Harvard Medical School, Wade E. Bolton, VentureWell/Rapid Acceleration of Diagnostics (RADx)
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- Book:
- Accelerating Diagnostics in a Time of Crisis
- Published online:
- 06 January 2024
- Print publication:
- 07 March 2024, pp 74-87
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Summary
Rapid Acceleration of Diagnostics (RADx®) Tech was the key diagnostics component of a three-pronged national strategy, including vaccines and therapeutics, to respond to the COVID-19 pandemic. Unprecedented in the scale of its mission, its budget, its accelerated time frame, the extent of cross-government agency collaboration and information exchange, and the blending of business, academic, and investment best practices, RAD Tech successfully launched dozens of US Food and Drug Administration Emergency Use Authorization diagnostic tests, established a new model for rapidly translating diagnostic tests from the laboratory to the marketplace, and accelerated public acceptance of home-based diagnostic tests. This chapter provides an overview of the processes utilized by RADx Tech during the COVID-19 pandemic to improve clinical laboratory tests and identify, evaluate, support, validate, and commercialize innovative point-of-care and home-based tests that directly detected the presence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.
Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders
- Matthew J. Y. Kang, Dhamidhu Eratne, Hannah Dobson, Charles B. Malpas, Michael Keem, Courtney Lewis, Jasleen Grewal, Vivian Tsoukra, Christa Dang, Ramon Mocellin, Tomas Kalincik, Alexander F. Santillo, Henrik Zetterberg, Kaj Blennow, Christiane Stehmann, Shiji Varghese, Qiao-Xin Li, Colin L. Masters, Steven Collins, Samuel F. Berkovic, Andrew Evans, Wendy Kelso, Sarah Farrand, Samantha M. Loi, Mark Walterfang, Dennis Velakoulis
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- Journal:
- Acta Neuropsychiatrica / Volume 36 / Issue 1 / February 2024
- Published online by Cambridge University Press:
- 28 April 2023, pp. 17-28
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Objective:
People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.
Methods:We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other.
Results:Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone.
Conclusions:CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.
Multi-decadal basal slip enhancement at Saskatchewan Glacier, Canadian Rocky Mountains
- Nathan T. Stevens, Collin J. Roland, Lucas K. Zoet, Richard B. Alley, Dougal D. Hansen, Emily Schwans
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- Journal:
- Journal of Glaciology / Volume 69 / Issue 273 / February 2023
- Published online by Cambridge University Press:
- 30 June 2022, pp. 71-86
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Glacier motion responds dynamically to changing meltwater inputs, but the multi-decadal response of basal sliding to climate remains poorly constrained due to its sensitivity across multiple timescales. Observational records of glacier motion provide critical benchmarks to decode processes influencing glacier dynamics, but multi-decadal records that precede satellite observation and modern warming are rare. Here we present a record of motion in the ablation zone of Saskatchewan Glacier that spans seven decades. We combine in situ and remote-sensing observations to inform a first-order glacier flow model used to estimate the relative contributions of sliding and internal deformation on dynamics. We find a significant increase in basal sliding rates between melt-seasons in the 1950s and those in the 1990s and 2010s and explore three process-based explanations for this anomalous behavior: (i) the glacier surface steepened over seven decades, maintaining flow-driving stresses despite sustained thinning; (ii) the formation of a proglacial lake after 1955 may support elevated basal water pressures; and (iii) subglacial topography may cause dynamic responses specific to Saskatchewan Glacier. Although further constraints are necessary to ascertain which processes are of greatest importance for Saskatchewan Glacier's dynamic evolution, this record provides a benchmark for studies of multi-decadal glacier dynamics.
235 Analysiss of TNBC Cell Lines Cultured a Novel Translational Breast Cancer Microphysiological System (BC-MPS)
- Katherine L. Hebert, Khoa Nguyen, Thomas Cheng, Madlin Alzoubi, Steven Elliott, Bridgette Collins-Burow, Elizabeth Martin, Frank Lau, Matthew Burow
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- Journal:
- Journal of Clinical and Translational Science / Volume 6 / Issue s1 / April 2022
- Published online by Cambridge University Press:
- 19 April 2022, p. 37
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OBJECTIVES/GOALS: Current approaches to drug development for the aggressive triple negative breast cancer rely on current 2D and 3D in vitro models which have limited capabilities. We have developed a translational microphysiological system that can maintain the human breast microenvironment to capture the complex interaction with the tumor microenvironment. METHODS/STUDY POPULATION: Three different TNBC cell lines were seeded in BC-MPS: MDA-MB-231 parental cell line, MDA-MB-231wiht the gene, LKB1 overexpressed, which is a tumor suppressor, and MDA-MB-231 with the enzyme, ERK5, an enzyme associated with increased metastasis and drug resistance, knocked out. These three TNBC cell lines were cultured in a standard 2D 96-well plate and in BC-MPS. Time-lapse videos were taken to track cellular mobility. RNA-sequencing was performed to compare different expression levels of various cancer related genes of the cell lines cultured in standard 2D and BC-MPS. RESULTS/ANTICIPATED RESULTS: The LKB1 overexpressed MDA-MB-231 and the ERK5-ko MDA-MB-231 cell lines are expected to have decreased mobility compared to the parental cells. The cell lines are expected to have increased expression of cancer related genes when cultured in BC-MPS than when cultured in standard 2D due to the presence of human breast tissue. DISCUSSION/SIGNIFICANCE: BC-MPS is a promising new translational MPS that facilitates studying long term interactions between real human breast tissue and cancer cells. The BC-MPS systems ability to support the growth of established cell lines has been demonstrated. Future studies will focus on developing the model for personalized medicine.
Comparing optimized exoskeleton assistance of the hip, knee, and ankle in single and multi-joint configurations
- Patrick W. Franks, Gwendolyn M. Bryan, Russell M. Martin, Ricardo Reyes, Ava C. Lakmazaheri, Steven H. Collins
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- Journal:
- Wearable Technologies / Volume 2 / 2021
- Published online by Cambridge University Press:
- 24 November 2021, e16
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Exoskeletons that assist the hip, knee, and ankle joints have begun to improve human mobility, particularly by reducing the metabolic cost of walking. However, direct comparisons of optimal assistance of these joints, or their combinations, have not yet been possible. Assisting multiple joints may be more beneficial than the sum of individual effects, because muscles often span multiple joints, or less effective, because single-joint assistance can indirectly aid other joints. In this study, we used a hip–knee–ankle exoskeleton emulator paired with human-in-the-loop optimization to find single-joint, two-joint, and whole-leg assistance that maximally reduced the metabolic cost of walking. Hip-only and ankle-only assistance reduced the metabolic cost of walking by 26 and 30% relative to walking in the device unassisted, confirming that both joints are good targets for assistance (N = 3). Knee-only assistance reduced the metabolic cost of walking by 13%, demonstrating that effective knee assistance is possible (N = 3). Two-joint assistance reduced the metabolic cost of walking by between 33 and 42%, with the largest improvements coming from hip-ankle assistance (N = 3). Assisting all three joints reduced the metabolic cost of walking by 50%, showing that at least half of the metabolic energy expended during walking can be saved through exoskeleton assistance (N = 4). Changes in kinematics and muscle activity indicate that single-joint assistance indirectly assisted muscles at other joints, such that the improvement from whole-leg assistance was smaller than the sum of its single-joint parts. Exoskeletons can assist the entire limb for maximum effect, but a single well-chosen joint can be more efficient when considering additional factors such as weight and cost.
56371 The Signaling Axis of Tumor Suppressor LKB1 in Triple Negative Breast Cancer
- Khoa Nguyen, Madlin Alzoubi, Katherine Hebert, Thomas Cheng, Steven Elliott, Matthew Burow, Bridgette Collins-Burow
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- Journal:
- Journal of Clinical and Translational Science / Volume 5 / Issue s1 / March 2021
- Published online by Cambridge University Press:
- 30 March 2021, p. 15
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ABSTRACT IMPACT: Identifying an important pathway in treatment resistant TNBC will allow for the future development of clinical therapeutics specific for this disease. OBJECTIVES/GOALS: Triple Negative Breast Cancer (TNBC) is a subtype of breast cancer characterized by negative expression of estrogen receptor, progesterone receptor, and HER2/neu amplification. It resists therapies and has a high recurrence rate after resection. The goal of my research is to identify & characterize a TNBC pathway for future development of therapies. METHODS/STUDY POPULATION: The project uses a combination of cell lines, patient derived xenograft (PDX) models, as well as patient databases. Standard cellular and molecular biology techniques will be used including: Cell culture, qPCR, western blotting, and flow cytometry. RESULTS/ANTICIPATED RESULTS: LKB1 is a master kinase that activates 14 possible downstream kinases. The signaling pathway has been demonstrated to play a role in energy homeostasis and metabolism. Mutation of LKB1 signaling results in Peutz-Jeghers Syndrome and is associated with neoplasias of the lung, pancreas, and breast. Based on preliminary analysis, overexpression of LKB1 by shRNA in TNBC cell lines results in suppression of EMT and reduction of the cancer stem cell population. Additional studies show that LKB1 overexpression has no effect on growth rate in 2D culture while significant reduction in 3D mammosphere formations can be seen. Downstream studies using commercially available SIK1 inhibitor HG-9-91-01 is able to induce a larger fraction of CSC from reduced LKB1 overexpression as well as from baseline levels. DISCUSSION/SIGNIFICANCE OF FINDINGS: Overall, our results suggest that LKB1 acts through SIK1 to suppress EMT and the generation of cancer stem cells. This results in reduced cancer functionality, as evidenced by inhibition of mammosphere formation. These results establishes a foundation for future mechanistic studies on the LKB1 axis and its mechanisms in TNBC.
Estimating the Relative Energy Content of Reactive Materials Using Nanosecond-Pulsed Laser Ablation
- Jennifer L. Gottfried, Steven W. Dean, Eric S. Collins, Chi-Chin Wu
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- Journal:
- MRS Advances / Volume 3 / Issue 17 / 2018
- Published online by Cambridge University Press:
- 16 January 2018, pp. 875-886
- Print publication:
- 2018
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Recently, a laboratory-scale method for measuring the rapid energy release from milligram quantities of energetic material has been developed based on the high-temperature plasma chemistry induced by a focused, nanosecond laser pulse. The ensuing exothermic chemical reactions result in an increase in the laser-induced shock wave velocity compared to inert materials. Laser-induced air shock from energetic materials (LASEM) provides a method for estimating the detonation performance of novel organic-based energetic materials prior to scale-up and full detonation testing. Here, the extension of LASEM to non-organic energetic materials is discussed. The laser-induced shock velocities from reactive materials such as Al/PTFE, Al/CuO, Al/Zr alloys, Al/aluminum iodate hexahydrate, and porous silicon composites have been measured; in many cases, the high sensitivity of the samples resulted in propagation of the reaction to the surrounding material, producing significantly higher shock velocities than conventional energetic materials. Methods for compensating for this effect will be discussed. Despite this limitation, the relative comparison of the shock velocities, emission spectra, and combustion behavior of each type of material provides some insight into the mechanisms for increasing the energy release of the material on a fast (μs) and/or slow (ms) timescale.
2 - Probabilistic Risk Analysis and Terrorism Risk
- Edited by Ali E. Abbas, University of Southern California, Milind Tambe, University of Southern California, Detlof von Winterfeldt, University of Southern California
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- Book:
- Improving Homeland Security Decisions
- Published online:
- 13 December 2017
- Print publication:
- 02 November 2017, pp 5-31
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Exposure to air pollution and tobacco smoking and their combined effects on depression in six low- and middle-income countries
- Hualiang Lin, Yanfei Guo, Paul Kowal, Collins O. Airhihenbuwa, Qian Di, Yang Zheng, Xing Zhao, Michael G. Vaughn, Steven Howard, Mario Schootman, Aaron Salinas-Rodriguez, Alfred E. Yawson, Perianayagam Arokiasamy, Betty Soledad Manrique-Espinoza, Richard B. Biritwum, Stephen P. Rule, Nadia Minicuci, Nirmala Naidoo, Somnath Chatterji, Zhengmin (Min) Qian, Wenjun Ma, Fan Wu
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- Journal:
- The British Journal of Psychiatry / Volume 211 / Issue 3 / September 2017
- Published online by Cambridge University Press:
- 02 January 2018, pp. 157-162
- Print publication:
- September 2017
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Background
Little is known about the joint mental health effects of air pollution and tobacco smoking in low- and middle-income countries.
AimsTo investigate the effects of exposure to ambient fine particulate matter pollution (PM2.5) and smoking and their combined (interactive) effects on depression.
MethodMultilevel logistic regression analysis of baseline data of a prospective cohort study (n=41785). The 3-year average concentrations of PM2.5 were estimated using US National Aeronautics and Space Administration satellite data, and depression was diagnosed using a standardised questionnaire. Three-level logistic regression models were applied to examine the associations with depression.
ResultsThe odds ratio (OR) for depression was 1.09 (95% CI 1.01–1.17) per 10 μg/m3 increase in ambient PM2.5, and the association remained after adjusting for potential confounding factors (adjusted OR = 1.10, 95% CI 1.02–1.19). Tobacco smoking (smoking status, frequency, duration and amount) was also significantly associated with depression. There appeared to be a synergistic interaction between ambient PM2.5 and smoking on depression in the additive model, but the interaction was not statistically significant in the multiplicative model.
ConclusionsOur study suggests that exposure to ambient PM2.5 may increase the risk of depression, and smoking may enhance this effect.
Response of Three Switchgrass (Panicum virgatum) Cultivars to Mesotrione, Quinclorac, and Pendimethalin
- Rick A. Boydston, Harold P. Collins, Steven C. Fransen
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- Journal:
- Weed Technology / Volume 24 / Issue 3 / September 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 336-341
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Annual grass weed control and switchgrass cultivar response to PRE-applied pendimethalin and POST-applied mesotrione and quinclorac was evaluated in 2005 and 2006 near Paterson, WA, in both newly seeded and 1-yr-old established switchgrass. Pendimethalin applied to newly planted switchgrass at 1.1 kg ai ha−1 at the one-leaf stage in 2005 or at 0.67 kg ha−1 PRE in 2006 severely injured and greatly reduced switchgrass stands. Mesotrione applied POST at 0.07 kg ai ha−1 injured newly planted switchgrass, reduced switchgrass height for several weeks after treatment, and reduced final switchgrass biomass by 54% both years. ‘Kanlow’ and ‘Cave-in-Rock’ cultivars were injured less by mesotrione than ‘Shawnee’ in 2005, whereas in 2006, Kanlow was injured less than Shawnee and Cave-in-Rock. Quinclorac applied POST at 0.56 kg ai ha−1 injured newly planted switchgrass less than mesotrione and pendimethalin but reduced final switchgrass biomass by 33% both years compared with treatment with atrazine alone. All three herbicide treatments controlled large crabgrass in the year of establishment. Green foxtail counts were reduced 93% or more by pendimethalin and quinclorac compared with nontreated controls, but mesotrione failed to control green foxtail. Pendimethalin applied PRE at 1.1 kg ha−1 did not injure 1-yr-old established switchgrass or reduce switchgrass biomass. Quinclorac applied POST at 0.56 kg ha−1 to established switchgrass reduced switchgrass biomass of the first harvest by 16% in 1 of 2 yr. Mesotrione applied POST at 0.07 kg ha−1 injured established switchgrass and reduced biomass of the first harvest by 33 and 17% in 2005 and 2006, respectively. Kanlow was injured the least by mesotrione in both years. Established switchgrass suppressed late-emerging annual grass weeds sufficiently to avoid the need for a grass-specific herbicide application.
White Sweetclover (Melilotus albus) and Narrowleaf Hawksbeard (Crepis tectorum) Seed Germination after Passing through Moose
- Steven S. Seefeldt, William B. Collins, Joseph C. Kuhl, Marcus Clauss
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- Journal:
- Invasive Plant Science and Management / Volume 3 / Issue 1 / May 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 26-31
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White sweetclover and narrowleaf hawksbeard are nonindigenous invasive plant species in Alaska that are rapidly spreading, including into areas that are otherwise free of nonindigenous plants. There has been concern that native moose could be dispersing germinable seed from these plants after ingestion. To address this concern, a study was conducted involving tame moose at the University of Alaska Fairbanks Agriculture and Forestry Experiment Station, Matanuska Experiment Farm, Palmer, AK. Objectives were to determine if seeds from these two plant species could survive mastication and digestive passage through moose, whether this passage impacted seed germination, and whether seed passage rates were the same as similar sized Cr-mordanted fiber. In this study, narrowleaf hawksbeard seed rarely survived mastication and digestion with only five seedlings recovered from 42,000 germinable seed fed to the moose. About 16% of germinable white sweetclover seed (3,595 of 22,000) fed to the moose produced seedlings. Most of the sweetclover seedlings came from feces produced 2 and 3 d after feeding. In two moose, sweetclover seedlings were grown from fecal material that was passed 11 d after feeding, raising the possibility that seeds could be transported long distances after ingestion. Cr-mordanted fiber passage did not closely follow seedling producing seed, possibly because time in the rumen might reduce seed germination. Once roadsides in Alaska become infested with white sweetclover, moose can then serve as a transport vector of these weeds into river channels and floodplains, which are distant from roads. This information will impact white sweetclover management programs and alert land managers to the potential for other instances of wildlife-mediated seed dispersal.
Axonal Damage in Multiple Sclerosis Patients with High versus Low Expanded Disability Status Scale Score
- Steven D. Brass, Sridar Narayanan, Jack P. Antel, Yves Lapierre, Louis Collins, Douglas L. Arnold
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- Journal:
- Canadian Journal of Neurological Sciences / Volume 31 / Issue 2 / May 2004
- Published online by Cambridge University Press:
- 16 February 2016, pp. 225-228
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Background:
The pathophysiological basis for differences in disability in patients with multiple sclerosis is unclear.
Methods:We used magnetic resonance imaging to examine whether differences in disability in cohorts of multiple sclerosis patients with similar T2-weighted lesion volume and disease duration were associated with a more destructive disease process in the more disabled patients.
Results:The benign and severely disabled groups had similar brain atrophy metrics and similar decreases of the neuronal marker, N-acetylaspartate, in the normal appearing white matter of the cerebrum on magnetic resonance spectroscopy examination in vivo. The severely disabled cohort had more spinal cord atrophy.
Conclusion:The dissociation of spinal cord atrophy and cerebral atrophy between these two groups suggests that the difference between the more benign and more disabled groups cannot be explained by a more aggressive pathological process that is affecting the entire neuroaxis in a homogeneous fashion.
Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute
- Jeffrey P. Jacobs, James A. Quintessenza, Tom R. Karl, Alfred Asante-Korang, Allen D. Everett, Susan B. Collins, Genaro A. Ramirez-Correa, Kristin M. Burns, Mitchell Cohen, Steven D. Colan, John M. Costello, Kevin P. Daly, Rodney C. G. Franklin, Charles D. Fraser, Kevin D. Hill, James C. Huhta, Sunjay Kaushal, Yuk M. Law, Steven E. Lipshultz, Anne M. Murphy, Sara K. Pasquali, Mark R. Payne, Joseph Rossano, Girish Shirali, Stephanie M. Ware, Mingguo Xu, Marshall L. Jacobs
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- Journal:
- Cardiology in the Young / Volume 25 / Issue S2 / August 2015
- Published online by Cambridge University Press:
- 17 September 2015, pp. 8-30
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In the United States alone, ∼14,000 children are hospitalised annually with acute heart failure. The science and art of caring for these patients continues to evolve. The International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute was held on February 4 and 5, 2015. The 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute was funded through the Andrews/Daicoff Cardiovascular Program Endowment, a philanthropic collaboration between All Children’s Hospital and the Morsani College of Medicine at the University of South Florida (USF). Sponsored by All Children’s Hospital Andrews/Daicoff Cardiovascular Program, the International Pediatric Heart Failure Summit assembled leaders in clinical and scientific disciplines related to paediatric heart failure and created a multi-disciplinary “think-tank”. The purpose of this manuscript is to summarise the lessons from the 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children’s Heart Institute, to describe the “state of the art” of the treatment of paediatric cardiac failure, and to discuss future directions for research in the domain of paediatric cardiac failure.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. 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- Edited by Robert Audi, University of Notre Dame, Indiana
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An Efficient, Energy Stable Scheme for the Cahn-Hilliard-Brinkman System
- Craig Collins, Jie Shen, Steven M. Wise
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- Communications in Computational Physics / Volume 13 / Issue 4 / April 2013
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- 03 June 2015, pp. 929-957
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We present an unconditionally energy stable and uniquely solvable finite difference scheme for the Cahn-Hilliard-Brinkman (CHB) system, which is comprised of a Cahn-Hilliard-type diffusion equation and a generalized Brinkman equation mod-eling fluid flow. The CHB system is a generalization of the Cahn-Hilliard-Stokes model and describes two phase very viscous flows in porous media. The scheme is based on a convex splitting of the discrete CH energy and is semi-implicit. The equations at the implicit time level are nonlinear, but we prove that they represent the gradient of a strictly convex functional and are therefore uniquely solvable, regardless of time step size. Owing to energy stability, we show that the scheme is stable in the time and space discrete and norms. We also present an efficient, practical nonlinear multigrid method . comprised of a standard FAS method for the Cahn-Hilliard part, and a method based on the Vanka smoothing strategy for the Brinkman part . for solving these equations. In particular, we provide evidence that the solver has nearly optimal complexity in typical situations. The solver is applied to simulate spinodal decomposition of a viscous fluid in a porous medium, as well as to the more general problems of buoyancy- and boundary-driven flows.
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. 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Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. 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Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
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Buddhist ‘nuns’ (mae chi) and the teaching of Pali in contemporary Thailand*
- STEVEN COLLINS, JUSTIN MCDANIEL
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- Journal:
- Modern Asian Studies / Volume 44 / Issue 6 / November 2010
- Published online by Cambridge University Press:
- 21 April 2010, pp. 1373-1408
- Print publication:
- November 2010
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This paper presents an ethnographic account of Buddhist ‘nuns’ involved in the teaching of Pali language and Abhidhamma in contemporary Thailand. It also reflects on both the emic-Buddhist (Pali and modern vernacular) and etic-interpretative (English-language) vocabularies which have been used to describe these women and their social role(s) and status(es). The aims of the paper are to go beyond the Weberian vocabulary usually used to describe what we will call ‘professionally celibate Buddhist women’, to escape from the ubiquitous emphasis on the issue of re-establising the Nuns’ Order (bhikkhunī-s) in the modern world in scholarship dealing with such women, and to encourage further ethnography and further civilizational interpretation of gender and asceticism.